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Furthermore, high activity of NF-B and increased production of DV2 was observed in HepG2 cells treated with BSO

Oxidative stress underlies a large number of diseases and dysfunctions associated with aging

Copper serves as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes essential for collagen cross-linking and structural integrity

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Topical effects Most reported topical effects are mild and local: redness, tingling, dryness, or transient irritation at the application site, typically more common with concentrations above 4%

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