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Ceriello A, Esposito K, Testa R, Bonfigli AR, Marra M, Giugliano D

Pediatr Clin North Am

NeuroToxicol 96:2836

doi: 10.1038/s41523-025-00723-0 143 KimSMoonBILimWParkSChoMSSungSH

[1] [2] The age-related drop in NAD+ levels is caused by rising levels of CD38, a membrane-bound NADase that degrades both NAD+ and its precursor nicotinamide mononucleotide, according to a 2016 study in mice, which exhibit age-related declines in NAD+ levels similar to those seen in humans