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V., Zhang C., Spokoyny A

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Unlike semaglutide, it mimics the GIP hormone as well as GLP-1

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Inhibition of the cAMP-degradation enzyme phosphodiesterase 4 (PDE4) can enhance and sustain these cAMP responses, whereas disruption of Gs or cAMP signaling in AP Glp1r neurons abolishes semaglutide-induced weight loss and downstream brain-wide activation