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Promising strategies include biomarker-guided, dual-immunotherapy combinations selected based on features like high tumor immunogenicity [261], Another approach involves the systemic remodeling of the immunosuppressive niche, for instance by neutralizing key microenvironmental factors such as GDF-15 to reinvigorate antitumor immunity [262], In summary, these converging technological advancesspanning precise monitoring, mechanism-informed therapy, and intelligent therapeutic sequencingcollectively provide the tools to systematically deconstruct the integrated biological networks that sustain MDR

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, ( Front Pharmacol