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Researchmainly preclinicalhas examined its potential to boost muscle growth through increased IGF-1 production, promote fat metabolism due to GHs lipolytic properties, and provide benefits related to cellular repair, recovery, and even anti-aging

Biochemical Journal 51:12933

Thus, high total IGF-I levels in CKD is inadequate in suppressing the increased GH levels because of the lower IGF-I bioactivity resulting in the lack of IGF-I feedback on pituitary GH secretion (75, 77) ( Table 1