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Common reactions may include pain, redness, or irritation at the injection site, mild diarrhea, nausea, itching, headache, dizziness, or a general feeling of swelling

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An intramuscular injection (commonly 1,000 mcg , given in the upper arm, hip or thigh) sidesteps the gut entirely and delivers a near-complete dose into circulation within minutes

Eli Lilly reported these results in mid-2025, and the retatrutide availability timeline now points toward potential FDA approval no earlier than 2027, as additional phase 3 trials continue

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