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Visual indicators include color change (from blue to green, brown, or cloudy), visible particles or precipitation, and unusual film or residue

Cho, S., Rasoulianboroujeni, M., Kang, R

94 A possible explanation for the retinopathy progression seen only in the SUSTAIN-6 trial is the substantial improvement in hemoglobin A1c (1.1% in the 0.5 mg group, 1.4% in the 1.0 mg group) because rapid improvement in glycemic control has been shown to transiently worsen retinopathy, particularly in type 1 diabetes

Cells were collected, and OMs were disrupted with glass beads and examined by TEM for the presence of nozzles 54

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