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According to Harvard Health Publishing , symptoms of testosterone deficiency include: Loss of facial and body hair, including baldness and less hair on their arms, legs, or chest An increase in breast size, causing excessive and unwanted breast tissue Irritability and depression Difficulty concentrating Testicles getting smaller Erectile dysfunction, reduced sperm count, and infertility Lost interest in sexual activity A decrease in muscle mass A decrease in bone mineral density, leading to brittle bones or osteoporosis Without sufficient testosterone levels, a man will also have difficulty building lean muscle, despite working out regularly