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& Robinson, J

RESULTS Impaired glucose and/or lipid metabolism, a sign of obesity and T2DM [6], increases hepatic gluconeogenesis and inhibits the peripheral utilization of glucose, which eventually could lead to insulin resistance [19]

The pipeline agents ecnoglutide, mazdutide, retatrutide land in the 1315% range, but the data are early

While approval of the drug for weight loss use is pending with the agency, many doctors commonly prescribe it off-label for their overweight patients

Typical dosing might range from one injection every 1-2 weeks, but this should always be determined by a medical professional

Both semaglutide (Wegovy) and tirzepatide (Zepbound) have Health Canada approval for weight management and produce meaningful results