2012 Dec;1826(2):443-57
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A well-designed glutathione conjugation strategy considers substrate electrophilicity, the role of the cysteine thiol versus terminal amino or carboxyl groups, protection and deprotection needs, solvent and pH compatibility, oxidation risk, and the downstream analytical question the customer actually needs to answer
We also note that some studies contradict these conclusions 53
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On the other hand, similar DNA protective action has been found also in the case of other polyphenols, e.g., quercetin, that decreased the levels of 8-hydroxydeoxyguanosine in kidney or liver cells following their exposure to oxidative stress 157,158,159