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Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)

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This creates a self-perpetuating cycle where inflammation drives weight gain, which in turn amplifies inflammation further

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Steady or improving numbers are a better sign of fat loss over muscle loss than the scale alone

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