Liver findings included lower liver weight, reduced triglyceride content and less severe histological features of steatosis and inflammatory-cell infiltration in treated mice
GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord
Where the evidence was convincing, we changed what we do
Using 29-31 gauge insulin syringes minimizes this issue
Depending on your individual needs, weekly or bi-weekly shots are common for sustained benefits
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism
