Tirzepatide mimics the action of two natural hormones released by intestinal cells: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
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Such cross reaction would probably cause diabetic reactions in patients and can therefore not be accepted
Hydroxocobalamin is preferred because it has a longer half-life and is retained in the body more effectively than cyanocobalamin (which is mainly available as oral supplements in the UK)