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Although a trend toward reduced HCC risk was observed, this failed to achieve statistical significance in the overall analysis (IRR: 0.82, 95%CI: 0.61-1.11, P = 0.189), possibly reflecting insufficient follow-up duration to capture the full impact on hepatocarcinogenesis

However, when the drug is used for short-term effects, it rarely causes adverse symptoms

These responses may include mild fatigue, changes in bowel patterns, or minor skin changes as the body increases its detoxification activity

How providers apply that distinction is a clinical decision made for individual patients