In different cell types, Nampt gene transcription is regulated by the circadian locomotor output cycles kaput/brain and muscle ARNT-like one (CLOCK:BMAL1) complex [38,198]
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Furthermore, given that calorie restriction-induced AMPK activation stimulates Nampt transcription [94], and metformin, an AMPK activator, activates intestinal AMPK [93,106,107,108], the effects of metformin administration on Nampt expression and GLP-1 production should be comprehensively tested in HFD-fed obese mice with impaired intestinal NAMPT-mediated NAD + biosynthesis [31]
Also, data analysis showed that the serum GLP-1 level of patients with newly diagnosed T2DM combined with CAS was significantly reduced compared with the control group
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