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It is about layering multiple strategies that address different aspects of the problem

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2016

This creates a parallel market operating outside clinical oversight and regulatory safeguards

(2018) 11:e201700127

Unfortunately, for many diseases and physiological states that can drive nausea and emesis (e.g., cancers, diabetes, cystic fibrosis, pregnancy) it is clear that the 5-HT3R and NK1R antagonists are suboptimal for the total control of malaise (1214), suggesting that there are other underlying neural substrates involved in the control of nausea and emesis