(73) had two types of intervention (L-carnitine supplementation + aerobic training and L-carnitine supplementation) so we considered two arms for this study
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
SPINS reported a 15.3% increase in sales of protein supplements, a 0.6% increase in probiotics, and a 0.2% increase in multivitamins
A key framework here is Chronic Inflammatory Response Syndrome (CIRS), a condition in which the immune system enters a state of persistent activation following biotoxin exposure
Ultimately, our health choices should empower us and align with our personal wellness journeys
DOI: 10.2217/epi-2023-0207 6