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When Palatin Technologies licensed Melanotan II from the University of Arizona, they initially pursued it for erectile dysfunction

Frontiers in Pharmacology , 13, p.964321

(2020) 9:e2000608

Activation of these receptors in the gastrointestinal tract results in delayed gastric emptyingthe rate at which food moves from the stomach into the small intestine is significantly reduced

Combined activation of both receptors may act synergistically providing additive effects on glucose and body weight in comparison of GLP1 analogues alone