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Nausea and Vomiting: Digestive disturbances can occur alongside liver issues

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Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease

There is also the question of what happens when GLP-1 therapy is eventually stopped: weight tends to return, suggesting that the underlying biology of obesity has not been fundamentally altered

( a ) Fasting plasma GIP (CON n = 11, Gipr AP-KO n = 12), ( b ) total GLP-1 (CON n = 11, Gipr AP-KO n = 12) ( c ) insulin (CON n = 11, Gipr AP-KO n = 12), ( d ) food intake post IPGTT, ( e ) ad lib fed blood glucose, ( f ) RER, ( g ) energy expenditure (inset, with ANCOVA using BW as covariate), ( h ) ambulatory activity (x beam breaks) of std chow fed (lean) mice ( d - h : CON n = 11, Gipr AP-KO n = 13, symbols as defined in f)