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PubMed DOI Pickart L, Vasquez-Soltero JM, Margolina A

Hydrocarbon-stapled peptides are covalently constrained alpha-helical peptidomimetics, synthesized by substitution of two strategically spaced residues with terminal olefin-containing unnatural amino acids, followed by ring-closing olefin metathesis (RCM) to cyclize the peptide

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