Key takeaways for mums: GLP-1 medications are not safe to take while breastfeeding
However, the glucagon receptor component is entirely new to your system, so starting at 1 mg is still recommended
The clinical investigators specifically noted that "gastrointestinal adverse events were partially mitigated by the use of a lower starting dose." Starting at 1 mg, which is what the Phase 3 TRIUMPH trials use, provides even more tolerability protection
The short half-life of glucagon-like peptide-1 in plasma does not reflect its long-lasting beneficial effects
Taking GLP-1s appears to alter these areas and change the levels of reward-related neurotransmitters dopamine and glutamate, a review of related studies suggests
But that drug is a peptide, delivering semaglutide in a large-molecule form that is harder to manufacture and requires more care when taking it