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It provides a powerful example of how healthcare data can support earlier diagnosis and more patient-centered care
They usually diminish as the body adjusts, but in some cases, they can be persistent and severe enough to require discontinuation of the medication
A 2025 Stanford Medicine study identifying a naturally occurring peptide that suppressed appetite and reduced body weight without the nausea and muscle loss associated with semaglutide confirmed what many clinicians had already observed: the GLP-1 mechanism is powerful, but it carries side effects tied directly to how it works
Diabetologia 46:17111713
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