1999, plasma half-life approximately two hours after intravenous administration in healthy male volunteers) measured growth hormone release as the sole pharmacodynamic readout and did not measure plasma cortisol, ACTH, or prolactin in humans [4]
Assisted reproduction cohorts are intrinsically heterogeneous: cycle type, progesterone route and exposure duration, stimulation protocol, embryo ploidy/PGT status, culture media formulation, incubator conditions, and laboratory workflow can each introduce systematic variance that may be comparable to biological effects across centres and protocols, and can mask or mimic true reproductive signals [462,463,464,465]
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