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In gouty arthritis, the intraarticular deposition of monosodium urate crystals activates the NLRP3 inflammasome, leading to the secretion of proinflammatory cytokines, including IL1, which mediate acute inflammatory responses

doi:10.1016/0168-9452(86)90016-6

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This study provides an early report of the loss of glial cells within the PFC of patients with mood disorders, consistent with the hypothesized glutamate abnormalities in these disorders

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This combination of broad documented activity and incomplete mechanistic understanding has made BPC-157 one of the most operationally interesting, and most actively studied, compounds in regenerative-peptide research literature