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Tumors have evolved a unique microenvironment, and typically display a more acidic condition, hypoxia, overexpressed reactive oxygen species (ROS), and glutathione (GSH) owing to their rapid proliferation and metabolism (Mura et al., 2013

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In addition to several classical drugs, a large number of dietary interventions and dietary/nutritional supplements, such as amino acids, probiotics, and plant-based extracts, have been tested or proposed for the treatment of long COVID, due to the usually good accessibility, affordability, safety, and easy application of the respective dietary/nutritional supplements [132]

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Preclinical work on GHK-Cu supports a role in collagen synthesis and tissue repair, though human trial data is limited