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1 Introduction Knee osteoarthritis (KOA) is a major cause of chronic pain, physical limitation, and reduced quality of life in middle-aged and older adults

Long-term oxidative stress accelerates ovarian aging by depleting the healthy oocyte reserve and damaging the follicle support microenvironment

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Patients at an increased risk are those with renal disease, on hemodialysis, or with a history of nephrolithiasis (5)

Typical recommended doses are 300-500 micrograms administered a few times weekly, but he advises caution against indiscriminate or continuous use without health monitoring 4

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