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GOT1 knockout combined with cysteine depletion by erastin or IKE showed potent antitumor effects against these cells by reducing GSH and increasing ferroptosis 66

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J Control Release

doi: 10.1210/jc.2003-031802 13 GeserickCMeyerH-AHaendlerB

It binds directly to IGF-1 receptors in muscle, bone, and adipose tissue, initiating anabolic cascades independent of upstream hormonal regulation

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