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10.3389/fphar.2021.732874 88 LiY.LiuX.SuS.YanH.GuoS.QianD.et al (2022)

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Why the Combination Is Common Anyway The pairing is popular in research and clinic marketing because CJC-1295 and Ipamorelin target different growth-hormone signaling pathways: Compound Class Primary Pathway FDA Status CJC-1295 GHRH analog GHRH receptor signaling Not approved Ipamorelin GHRP / ghrelin mimetic GHS-R1a signaling Not approved CJC-1295 + Ipamorelin Combination research blend Dual pathway GH secretagogue model Not approved Mechanistic complementarity is not the same as regulatory approval