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Once a patient is on a maintenance dose, their B12 levels are generally stable, and a single days difference is unlikely to have a clinical impact

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Blood Sugar Results in Type 2 Diabetes In the SOLSTICE Phase 2b trial, adults with type 2 diabetes experienced significant improvements in glucose control

Additionally, if you have baseline metabolic syndrome, elevated fasting glucose, or a family history of type 2 diabetes, you may respond more robustly to higher doses because your metabolism has greater glucose-handling dysfunction to reverse

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10.1007/s40256-019-00384-y 25 KhanS