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In addition, ROS also lead to mitochondrial autophagy impairment, biomolecule damage, and microglial overreactivity, as well as promoting the release of inflammatory factors and inducing neuroinflammation (Imbriani et al., 2022)

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The PD-1/PD-L1 axis assumes a crucial function in facilitating the evasion of immune surveillance by malignant tumors and promoting their progression [23, 27]