As an endogenous human tripeptide used topically for decades in skincare, GHK-Cu is generally regarded as well tolerated, with the most common issues being local irritation, redness, or contact sensitivity in susceptible individuals
It would also be pertinent to include a cohort of neurotypical children in a similar study to compare any changes in glutathione levels and behaviors in that population with those of children with ASD
Peptides present a problem: many are naturally occurring or simple enough that strong patent protection is difficult
While B12 is water-soluble with no established upper safe limit (according to NHS and EFSA guidance), this does not preclude the possibility of adverse reactions, particularly from injectable forms
In clinical use, the most commonly reported side effects are: Mild injection site redness or swelling (resolves within hours) Occasional lightheadedness following injection (less common, position-dependent) Temporary nausea with oral administration in some patients Who should not use BPC-157: Patients with active cancer or a history of cancer should discuss BPC-157 carefully with their oncologist before use angiogenic peptides theoretically could support tumor vascularity, though no evidence of this has been demonstrated in animals
Kanayama G et al