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For many patients, it is the safest and most comfortable way to transition forward

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For healthcare systems and policymakers, the evidence supports cautious optimism tempered by realistic acknowledgment of current limitations and the need for comprehensive approaches that address pharmacological efficacy, access, sustainability, and equity concerns

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These complications are extensive and diverse, encompassing metabolic disorders such as type 2 diabetes 2 , dyslipidemia 3 , cardiovascular diseases 4 and an increased overall mortality risk 5