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18 Intranasal administration of reduced GSH, (in)GSH, could be an effective approach for delivery of GSH to the CNS

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In addition, consistent with the findings reported elsewhere, we found DMF induces the activation of NRF2, and NRF2 targets such as those involved in cystine uptake (SLC7A11) and GSH biosynthesis (GCLM and GCLC, the mediator and catalytic subunits of GCL) (Fig

Therapeutic proteins would be released in the interstitial space [14] or intracellularly [20] by specific protease sites engineered between the GST and the therapeutic protein