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They act like a medicinal bullet that is delivered directly to a target area of the body

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Vasodilation is achieved by activating endothelial nitric oxide synthase (eNOS) and increasing nitric oxide (NO) production via the cAMP/PKA, AMPK, and PI 3 K/Akt signaling pathways [17]

doi: 10.1053/j.gastro.2023.05.050 2