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Traditional Cholesterol Medications Statins remain the first-line treatment for high cholesterol, but they work through a completely different mechanismblocking cholesterol synthesis in the liver

Pharmacodynamically, tirzepatide is an imbalanced co-agonist, favoring GIPR over GLP-1R, with a comparable affinity for GIPR as endogenous GIP and marginally lesser affinity for GLP-1R than endogenous GLP-1

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This risk increases significantly when the products are not administered by qualified professionals or sourced from questionable suppliers

Gastroenterology 98 :14521459

Frontiers in Pharmacology, 7 , 31