The primary advantage is improved convenience and potentially better adherence, as patients only need to remember one injection per week
It points to five key drugs: Lillys Mounjaro and four drugs by Novo NordiskOzempic, Wegovy, CagriSema (semaglutide and cagrilintide) (now in late-stage development), and Rybelsuswhich collectively are forecast to capture 83% of the GLP-1 agonist market by 2029
GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel
Wegovy is available through a range of options including US pharmacies such as CVS and Costco, select telehealth providers including Ro, LifeMD and Weight Watchers, NovoCare Pharmacy, GoodRx and others
GLP-1 medications arent short-term fixes
We believe the number of undiagnosed and clinically affected cases may be large and clinicians should therefore be aware of the adverse effects on mitochondrial function of sertraline
