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Many widely used medications were never FDA-approved for the conditions they treat

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The CES-D scale: a self-report depression scale for research in the general population

To that end, DHEA may:6 Interact with prescription medications (particularly those for mental health, including SSRIs, antipsychotics, carbamazepine, lithium, and valproic acid) Worsen psychiatric disorders and increase the risk of mania in people with mood disorders Reduce HDL (good) cholesterol levels Increase the risk of hormone-sensitive cancers (prostate, breast, and ovarian) Lead to oily skin, acne, or hirsutism in women (male-pattern hair growth) For more information on the potential drug interactions, you can find extensive lists from the Mayo Clinic and Mount Sinai

doi: 10.1021/acsnano.4c02420 107 GoodmanRSJohnsonDBBalkoJM