Importantly, AOD9604 achieved these effects without activating the growth-promoting pathways that full-length growth hormone uses, which is why it doesnt cause the unwanted side effects of growth hormone therapy such as insulin resistance or abnormal growth
This affects convenience and dosing accuracy
Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations
Angiogenesis cuts both ways: The pro-angiogenic, pro-migration mechanisms that make these peptides interesting for repair are the same processes that are undesirable in the presence of malignancy an unresolved theoretical concern and a genuine reason for caution
A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss
No evidence of genotoxic activity was found in either assay