Other At-Risk Groups GLP-1 medications are generally not suitable for individuals with severe gastrointestinal disorders like gastroparesis, those with type 1 diabetes (as these drugs are approved only for type 2 diabetes and obesity), and people with a history of suicidal thoughts, active eating disorders, or heavy alcohol use
prevalence: 1015% More frequent in women Typical onset: late teens to 40s Etiology / Risk Factors Multifactorial: Altered gut motility Visceral hypersensitivity Brain-gut axis dysregulation Post-infectious (after gastroenteritis) Psychological stress, anxiety, depression Food triggers: dairy, caffeine, high FODMAP foods Clinical Features Core symptoms (Rome IV criteria): Recurrent abdominal pain 1 day/week in the last 3 months Associated with two or more: Improvement with defecation Change in stool frequency Change in stool form (appearance) Other features: Bloating, gas Mucus in stool Alternating constipation and diarrhea Normal physical exam between episodes Red flags (require further workup): Weight loss, GI bleeding, anemia Fever, nocturnal symptoms Onset after 50 years Subtypes of IBS 1
Amaral FGD, Cipolla-Neto J
Long-term estrogen therapy without a progestogen in women with a uterus is associated with an elevated risk of endometrial neoplasia
In 2005, vitamin industry entrepreneurs created Celsius
Studien zeigen, dass die Kombination mit 80 g Kohlenhydraten die Muskel-L-Carnitin-Akkumulation deutlich verbessert
