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Countries party to TRIPS-plus bilateral trade agreements with the United States face additional constraints in implementing patent policies that would differentiate device patents from compound patents in ways that accelerate generic entry

While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

2010 June

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Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis