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Label transfer of primary hypothalamic neurons onto hPSC-derived neurons was performed by finding the 10 nearest primary hypothalamic neurons neighbours for each hPSC-derived neurons using the queryKNN function from the BiocNeighbors R package on the integrated space, followed by assigning the most common primary hypothalamic neuron cell type from the neighbouring cells

Side Effects Like most GLP-1-based medications, Mounjaro may cause: Nausea Diarrhea or constipation Reduced appetite Abdominal bloating or discomfort Headache or fatigue (less common) Most side effects improve as the body adapts

This dual receptor engagement produces distinct metabolic effects that are the subject of active comparative laboratory research

Both medications provide substantial health benefits, with the best choice depending on individual circumstances rather than the superior efficacy of one over the other

It's not just a matter of convenience

Special considerations and edge cases Breastfeeding and GLP-1 with hormones Postpartum women sometimes seek GLP-1 medications for weight loss while using hormonal birth control