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Food and Drug Administration (FDA) in May 2022 for the treatment of type 2 diabetes [1]

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As further proof, we inhibited transketolase (non-oxPPP) activity by oxythiamine and observed a decrease in UMP m+2 labelling in both genotypes, but only WT chondrocytes showed an upregulation of UMP m+1 labelling, indicating that only WT cells could increase oxPPP activity as compensation (Extended Data Fig

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