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GLP-1 users deal with both ends of the digestive disruption spectrum: constipation from slowed gastric emptying, and loose stools when the gut is adjusting

PMID: 10328106

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17 Antidiabetic agents in development A new generation of antidiabetic therapeutics is reshaping the landscape of metabolic medicine, emphasizing precision receptor modulation, multi-agonist synergy, and oral bioavailability

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess