Due to the compounds plasma half-life of approximately 3.86.9 hours, twice-daily (BID) dosing may provide more sustained NNMT inhibition
If your deficiency has been long-standing, full mood recovery may take longer and often depends on addressing other contributing factors (sleep, stress, hormones) in parallel
They might suggest blood tests to check for anaemia or thyroid problems, an internal examination, or an ultrasound scan to look for fibroids
If left out overnight or for a full day, significant degradation will have occurred, and we would recommend discarding the vial to ensure data accuracy
A few commenters believed it would increase burden to hospitals
20.9% in SURMOUNT-1, Jastreboff 2022 NEJM)