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Degradation was slower than for hGLP-1 but clearly measurable, with less than 50% uncleaved pGLP-1 and eGLP-1 remaining after 11 hours of incubation (Table 1)

Clinical studies have shown that weight loss with tirzepatide typically continues as long as the medication is used, with the most significant results often seen within the first 12 to 18 months

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Frontiers in Psychiatry, 12 , 665742