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However, deeper or more stubborn pigmentation may require in-office treatments or prescription-strength options, says Dr

The SUSTAIN 6 cardiovascular outcomes trial, which followed patients for a median of 2.1 years, demonstrated a 26% reduction in the primary composite endpoint of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke compared to placebo

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Indeed, randomized double-blind placebo-controlled trials, with extended time frame and large number of patients, are encouraged to clinically evaluate the role of riboflavin in PD and migraine headache patients