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Disulfiram inhibits aldehyde dehydrogenase, preventing the breakdown of acetaldehyde and resulting in an adverse reaction if alcohol is consumed

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found that acetaminophen causes concentration-dependent neuronal death in vitro at concentrations that are reached in human plasma during acetaminophen overdose, and are reached in the cerebrospinal fluid of rats for 3 h following doses that are below those required to induce acute hepatic failure in rats

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