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This is due to both drugs affecting platelet function

These metabolites not only modulate microbial composition but also act as Epi-drugs 179,180

However, extrahepatic metastases of ICC have rarely been reported in patients with rectal symptoms as initial symptoms, and the diagnosis relies on the specific immunohistochemical features of intestinal lesion biopsy

This review synthesizes evidence that BBR exerts its anti-diabetic effects through multi-tiered mechanisms converging on the amelioration of insulin resistance and systemic inflammation