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When NNMT is overactive, it consumes excess NAD+, leaving less available for these critical processes
The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity
If you want an oral, research-backed supplement to support metabolic health, investigate options with human clinical trials, like Motus (oral), and discuss them with a clinician
Potential Hormonal Effects: Animal studies suggest possible indirect effects on growth factors or hormone regulation, but human relevance is unclear
The fact that acne often coincides with the start of puberty adds to feelings of uncertainty about self-image and can contribute to emotional issues
