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A prospective analysis of the PLCO cancer screening trial cohort by Reichard et al (80) demonstrated that elevated circulating TMAO levels were markedly associated with an increased risk of lethal PCa, suggesting that TMAO may actively participate in disease progression and lethal transformation

12 Specifically, the p53 R175H mutation decreases the binding affinity of the DBD and Zn 2+ and promotes incorrect folding and inactivation of the p53 protein

doi: 10.1016/S2213-8587(22)00047-X 7 SjstrmLNarbroKSjstrmCDKarasonKLarssonBWedelHet al

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: Informed Choice certified, our capsules are rigorously tested for banned substances and devoid of artificial flavors, colors, and preservatives